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The Friday MLB schedule is loaded with 15 video games and all 30 MLB groups scheduled to play. One of the vital notable MLB matchups immediately is Twins vs. Astros in a battle between groups within the thick of the American League playoff race. Chris Paddack (2-5, 3.53 ERA) is scheduled to begin for Minnesota, whereas Colton Gordon (1-1, 5.11 ERA) can be on the mound for Houston. The SportsLine Projection Mannequin is looking for a powerful efficiency from Houston, with the Astros protecting (+1.5) on the run line. The Astros are -113 favorites on the moneyline within the newest Astros vs. Twins odds for Friday. 

The mannequin can be calling for the Seattle Mariners, led by MLB house run chief Cal Raleigh, to snap a three-game dropping streak and beat the Cleveland Guardians on the money-line at -114 odds. SportsLine is projecting a closing rating of 4.3-3.6 in Seattle’s favor for this sport. Earlier than making some other MLB picks or constructing any MLB parlay playing cards, you may wish to see the MLB predictions and betting recommendation from SportsLine’s confirmed laptop simulation mannequin. You may also try our MLB prop picks and our MLB house run picks for Friday.

The SportsLine Projection Mannequin simulates each MLB sport 10,000 occasions. It enters Week 12 of the 2025 MLB season on a 27-23 run on top-rated MLB sides picks. It has excelled making house run prop picks, returning greater than 35 models of revenue over the previous two months. Anyone following at sportsbooks and on betting apps might have seen sturdy returns.

The mannequin has damaged down the MLB odds for Friday and simply revealed its prime picks and MLB participant props. Combining the mannequin’s 4 picks into an MLB parlay would end in a payout of +1216 (danger $100 to win $1,216). New customers may even benefit from the DraftKings promo code providing $300 in bonus bets immediately with a $5 wager.

Listed below are its greatest bets for the MLB slate on Friday.

  • Tyler Stephenson over 0.5 whole RBI (+200)
  • Seattle Mariners moneyline (-114) vs. Cleveland Guardians
  • Houston Astros (+1.5) on the run line (-197) vs. Minnesota Twins
  • San Diego Padres (+1.5) on the run line (-182) vs. Arizona Diamondbacks
  • Mix these picks for a shot at a +1216 payout (odds topic to vary)  

Tyler Stephenson over 0.5 whole RBI (+200)

Stephenson has developed into an above common offensive catcher, and enters Friday’s matchup with the Detroit Tigers driving a three-game hit streak. For the season, Stephenson is batting .241 with 5 house runs and 16 RBI. SportsLine’s mannequin has an fringe of 0.3 based mostly on the projection of 0.8 RBI for Stephenson and the consensus line of 0.5.

Seattle Mariners moneyline (-114) vs. Cleveland Guardians

The Mariners can be out to snap a three-game dropping streak and may have right-hander Luis Castillo (4-4, 3.31 ERA) on the mound. Seattle additionally has a official MVP candidate behind the plate in Cal Raleigh, who leads the Majors in house runs with 26. The SportsLine Projection Mannequin is predicting a closing rating of 4.3-3.6 within the Mariners’ favor, with Seattle profitable in 63% of laptop simulations.

Houston Astros (+1.5) on the run line (-197) vs. Minnesota Twins

This matchup options two groups within the thick of the American League playoff race. This sport can be performed at Daikin Park in Houston, the place the Astros have carried out properly in 2025, going 24-13 total. The Astros are 2-1 file on the run line of their final 3 video games towards the Twins, and have the additional benefit of being house underdogs on Friday. The SportsLine Projection Mannequin is predicting a closing rating of 4.7-4.6 within the Astros’ favor, with Houston protecting in 69% of laptop simulations.

San Diego Padres (+1.5) on the run line (-182) vs. Arizona Diamondbacks

Arizona is driving a three-game profitable streak, however will face a tricky check in San Diego beginning pitcher Stephen Kolek (3-1, 3.00 ERA) on Friday. Up to now this season, the Padres are 3-0 on the run line when they aren’t favored and enjoying on the highway. The SportsLine Projection Mannequin is predicting a closing rating of 4.9-4.8 in Arizona’s favor, with the Padres protecting in 67% of laptop simulations.

Need extra MLB picks for immediately?

You have seen a few of the mannequin’s MLB greatest bets for Friday. Now, get run line, whole and money-line picks for each sport right here, all from the mannequin that is simulated each sport 10,000 occasions. 

Additionally at SportsLine:
You may also see immediately’s prime MLB picks from knowledgeable Matt Severance, who’s on a scorching 153-79 roll on his final 232 MLB picks. Go to SportsLine to see his greatest performs for immediately, all from the knowledgeable who’s up greater than 21 models. 

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