The Wednesday MLB schedule is loaded with 15 video games and all 30 MLB groups scheduled to be in motion, giving ample alternatives to make MLB betting picks. Probably the most notable MLB matchups is Blue Jays vs. Guardians at 6:40 p.m. ET in Cleveland. Veteran Max Scherzer will make his second begin of the season for Toronto and the SportsLine Projection Mannequin is asking for Scherzer to have a robust outing. The truth is, the mannequin says he finishes with over 4.5 complete strikeouts at +103 within the newest MLB odds (danger $100 to win $103) and MLB props. SportsLine’s mannequin can also be selecting the Guardians to cowl (+1.5) on the run line at -192 odds.

One other marquee matchup is Yankees vs. Reds in Cincinnati in a battle between groups trying to go on playoff runs. Cy Younger candidate Max Fried might be on the mound for the Yankees, and SportsLine expects one other productive begin from the 31-year-old lefthander. The mannequin is backing Fried to complete with over 18.5 complete pitcher outs at +142 within the newest MLB props. Earlier than making every other MLB picks or constructing any MLB parlays, you may wish to see the MLB predictions and betting recommendation from SportsLine’s confirmed laptop mannequin. You can even take a look at our MLB prop guess picks and MLB dwelling run picks for Wednesday.

The SportsLine Projection Mannequin simulates each MLB sport 10,000 occasions. It enters Week 14 of the 2025 MLB season on a worthwhile 41-32 run on top-rated MLB picks. It has excelled making dwelling run prop picks this season, returning greater than 22 items of revenue. Anyone following at sportsbooks and on betting apps might have seen robust returns.

The mannequin has damaged down the MLB odds for Wednesday and simply revealed its prime picks and MLB participant props. Combining the mannequin’s 4 picks into an MLB parlay would end in a payout of +1445 (danger $100 to win $1,445). New customers may even reap the benefits of the DraftKings promo code providing $150 in bonus bets immediately with a $5 wager.

Listed below are its greatest bets for the MLB slate on Wednesday.

• Max Scherzer Over 4.5 complete strikeouts (+103)
• Max Fried Over 18.5 complete outs (+142)
• Jorge Polanco Over 0.5 complete RBI (+170)
• Cleveland Guardians (+1.5) on the run line vs. Toronto Blue Jays (-192)
• Mix these picks for a shot at a +1917 payout (odds topic to vary)  

Max Scherzer Over 4.5 complete strikeouts (+103)

Scherzer is without doubt one of the prime MLB pitchers of his era, and is scheduled to make his second begin of the season on Tuesday. The 40-year-old was shaky in his first begin, giving up two solo dwelling runs in 3.0 innings of labor. The mannequin is asking for a bounce again efficiency from Scherzer on Wednesday. SportsLine provides this decide an fringe of 0.6 based mostly on the projection of 5.1 strikeouts and the consensus line of 4.5. New customers can improve their guess with the newest FanDuel promo code:

Max Fried Over 18.5 complete outs (+142)

Fried has lived as much as expectations in his first season with the Yankees. Over the span of 5 street video games, Fried has gone over his complete pitcher outs line 3 times, sustaining a mean of 19.0 complete pitcher outs per sport. The American League Cy Younger candidate enters Wednesday with a 9-2 document, 2.05 ERA, and 0.96 WHIP. New customers can snag as much as $1,500 in bonus bets with the newest BetMGM bonus code:

Jorge Polanco Over 0.5 complete RBI (+170)

Polanco and the Mariners are in Minnesota to tackle the Twins on Wednesday. The 31-year-old outfielder spent the primary 10 years of his profession with the Twins, and he has 139 profession dwelling runs. Polanco enters Wednesday batting .252 with 11 dwelling runs and 36 RBI in 2025. SportsLine provides this decide an fringe of 0.3 based mostly on the projection of 0.8 and the consensus line of 0.5. New customers can double their winnings on 10 bets with the newest Fanatics Sportsbook promo code:

Cleveland Guardians (+1.5) on the run line vs. Toronto Blue Jays (-192)

The Guardians host the Blue Jays on Wednesday, with Max Scherzer (0-0, 6.00 ERA) set to begin for Toronto and Gavin Williams (5-3, 3.58 ERA) set to begin for Cleveland. The mannequin is anticipating a decent sport all through, with the Blue Jays holding a slender edge. The SportsLine Projection Mannequin is predicting a ultimate rating of 4.5-4.4 within the Blue Jays’ favor, with Cleveland overlaying in 69% of laptop simulations.

Need extra MLB picks for at the moment?

You’ve got seen a few of the mannequin’s MLB greatest bets for Wednesday. Now, get run line, complete and money-line picks for each sport right here, all from the mannequin that is simulated each sport 10,000 occasions. 

Additionally at SportsLine:
You can even see at the moment’s prime MLB picks from skilled Matt Severance, who’s on a scorching 170-94 roll on his final 264 MLB picks. Go to SportsLine to see his greatest performs for at the moment, all from the skilled who’s up greater than 18 items.